Assisted Hatching in Cyprus

In all pregnancies the embryo must attach to the lining of the uterus. To do this, the embryo divides to form a “blastocyst” (multi-cell embryo with a fluid cavity). The blastocyst is covered by a gel-like substance called the “zona pellucida” or “Zona”. In order for the blastocyst to implant in the uterus wall, the cells must first break through the zona. This process is known as hatching. It is thought that in embryos created by IVF/ICSI the ability for a blastocyst to hatch is impaired.

Assisted Hatching is a laboratory procedure where the zona of the embryo is laser, mechanically or chemically weakened in a way that assists the embryo to “hatch” from the zona more easily and thus allow implantation into the lining of the uterus. You may be a candidate for assisted hatching if you are 37 years of age or older, have an elevated basal FSH level, or if you have previously had one or more IVF cycles with failure of your embryos to implant despite otherwise good results.
HLA-G (Human Leukocyte Antigen G), is a human gene. When HLA-G is secreted by the embryo, the mother’s immune system is less likely to reject the embryo. Embryos which secrete HLA-G are therefore more likely to implant successfully into the uterus. In light of this information, when selecting embryos we try to ensure the presence of HLA-G.

EmbryoGlue® is a media designed for embryo transfer. It contains hyaluronan and nutrients that are required to support the embryo during implantation. At Dogus, we use EmbryoGlue® to increase the chances of pregnancy in women who have previously experienced problems with implantation.